Toremifene Citrate, also known as Fareston, is a Selective Estrogen Receptor Modulator (SERM) similar to Tamoxifen Citrate (Nolvadex). Toremifene Citrate is used to treat breast cancer in post-menopausal women. It does this by exerting estrogen antagonistic effects in certain tissue, most notably, breast tissue. This is actually the same mechanism of action found in Tamox. This is why tamox is often recommended to researchers who are trying to avoid gynecomastia. Toremifene Citrate has several other well known effects, which are not simply limited to preventing the abnormal growth of breast tissue.

At the hypothalamus and pituitary, estrogen acts in cooperation with the male subject body’s negative feedback loop to send a signal to decrease the secretion of LHand FSH. When LH secretion is lowered, so are natural testosterone levels. Toremifene Citrate may even act as an estrogen antagonist in the hypothalamus and pituitary, which would also increase testosterone production. Because its androgenicity to estrogenicity ratio is 5x that of tamoxifene, Toremifene citrate is highly likely to be capable of increasing testosterone.